ATP is necessary for the production of cellular energy. A low ejection fraction is a classic symptom of congestive heart failure. As its name implies CoQ10 is a coenzyme that is necessary for the proper functioning of other substances, one of the most important of which is ATP (adenosine triphosphate). Other clinical trials followed prescribing the same level of supplementation with similar results. clinical study prescribed daily supplementation with 100 mg of the coenzyme for treatment periods of three months for patients with low ejection fraction measurements.
Among these conditions were the following: Valvular heart disease (pertaining to dysfunction of heart valves), hypertension, diastolic dysfunction (failure of the heart to properly refill itself with blood), dilated cardiomyopathy (group of disorders where the heart muscle is weakened and enlarged and cannot pump effectively) and ischemic cardiomyopathy (low oxygen state usually due to obstruction of the arterial blood supply). People who had received treatments early in the development of the disease showed the most dramatic improvement often returning to normal heart function. Similar observations were made in a trial involving 2,664 patients treated with CoQ10 at levels up to 150 mg per day.
During the one-year follow-up period 118 patients in the placebo group were hospitalized for heart failure compared to 73 in the group that received the supplements. Unlike previously noted studies this one followed the patients??? progress for six years.One early Japanese trial (1972) involved 197 patients with varying levels of severity of cardiac failure. Overall results demonstrated measurable cardiac improvements in one month with maximum improvements at about six months.
They were then followed-up for up to eight years with an average follow-up period of 18 months. These trials have been presented in this essay in thumbnail format. The other group received CoQ10 supplements.A 1994 study involving 424 patients with a variety of myocardial (refers to the heart’s muscle mass) diseases. Again, significant improvements in heart function were reported. However, discontinuing the treatment usually resulted in a decline of cardiac function with eventual return to pre-treatment conditions. The study reported significant improvement of cardiac function supplementing with 30 mg per day of CoQ10.Patients were treated with an average of 240 mg of CoQ10 daily during their treatment period. By proxy CoQ10 is likewise essential for this process.As always in the medical community many more studies will need to be conducted to determine the future of CoQ10 treatment.
Long-term benefits from CoQ10 supplementing were noticed with no harmful side effects.T.Clinical trials have attempted to study the relationship between CoQ10 and many chronic diseases including, but not limited to, heart disease, cancer and AIDS. Another Japanese study demonstrated similar results with 38 patients also supplementing with 30 mg. Through the years it has become increasing clear that the greatest improvements were shown in patients that had suffered from their condition the least amount of time.
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